| Host: | Rabbit |
| Applications: | WB/ICC/IF/FC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal anti-GATA4 for use in WB, ICC, IF and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | R04-3C1 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification: | Affinity Chromatography |
| Dilution Range: | WB 1:500-1:1000IF 1:50-1:200FC 1:50-1:100 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | GATA4 |
| Gene ID: | 2626 |
| Uniprot ID: | GATA4_HUMAN |
| Immunogen: | A synthesized peptide derived from human GATA4 |
| Post Translational Modifications | Methylation at Lys-300 attenuates transcriptional activity. |
| Function | Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development. May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase. |
| Protein Name | Transcription Factor Gata-4Gata-Binding Factor 4 |
| Database Links | Reactome: R-HSA-2032785Reactome: R-HSA-400511Reactome: R-HSA-5578768Reactome: R-HSA-9690406Reactome: R-HSA-9733709Reactome: R-HSA-9758920Reactome: R-HSA-9823730Reactome: R-HSA-983231Reactome: R-HSA-9925561 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Gata-4 antibodyAnti-Gata-Binding Factor 4 antibodyAnti-GATA4 antibody |
Information sourced from Uniprot.org
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