Anti-GAST antibody (50-100) {Biotin} (STJ501302)

SKU:
STJ501302-100

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Host: Rabbit
Applications: CM/ELISA/ICC/IF/IHC/IP/WB
Reactivity: Human/Monkey/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GAST (50-100) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55-0.75 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:150
IHC: 1:50-1:200
ICC: 1:50-1:200
IF: 1:50-1:200
CFM: 1:50-1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: GAST
Gene ID: 2520
Uniprot ID: GAST_HUMAN
Immunogen Region: 50-100
Immunogen: Synthetic peptide taken within amino acid region 50-100 on human Gastrin preprotein.
Post Translational Modifications Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
Function Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
Protein Name Gastrin Cleaved Into - Gastrin-71
Gastrin Component I - Gastrin-52
G52 - Big Gastrin
Gastrin Component Ii
Gastrin-34
G34 - Gastrin
Gastrin Component Iii
Gastrin-17
G17 - Gastrin-14
G14 - Gastrin-6
G6
Database Links Reactome: R-HSA-416476
Reactome: R-HSA-881907
Cellular Localisation Secreted
Alternative Antibody Names Anti-Gastrin Cleaved Into - Gastrin-71 antibody
Anti-Gastrin Component I - Gastrin-52 antibody
Anti-G52 - Big Gastrin antibody
Anti-Gastrin Component Ii antibody
Anti-Gastrin-34 antibody
Anti-G34 - Gastrin antibody
Anti-Gastrin Component Iii antibody
Anti-Gastrin-17 antibody
Anti-G17 - Gastrin-14 antibody
Anti-G14 - Gastrin-6 antibody
Anti-G6 antibody
Anti-GAST antibody
Anti-GAS antibody

Information sourced from Uniprot.org

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