Anti-GAS2 antibody (1-100) [S5146RM] (STJ11105146)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Growth Arrest-Specific Protein 2 (1-100) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5146RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GAS2 |
| Gene ID | 2620 |
| Uniprot ID | GAS2_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MCTALSPKVRSGPGLSDMHQ YSQWLASRHEANLLPMKEDL ALWLTNLLGKEITAETFMEK LDNGALLCQLAETMQEKFKE SMDANKPTKNLPLKKIPCKT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human GAS2 (NP_005247.1). |
Additional Info
| Tissue Specificity | Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen. |
| Post Translational Modifications | Cleaved, during apoptosis, on a specific aspartic residue by caspases. Phosphorylated on serine residues during the G0-G1 transition phase. |
| Function | Required to maintain microtubule bundles in inner ear supporting cells, affording them with mechanical stiffness to transmit sound energy through the cochlea. |
| Protein Name | Growth Arrest-Specific Protein 2Gas-2 |
| Database Links | Reactome: R-HSA-264870 |
| Cellular Localisation | CytoplasmCytoskeletonStress FiberMembranePeripheral Membrane ProteinComponent Of The Microfilament SystemColocalizes With Actin Fibers At The Cell Border And Along The Stress Fibers In Growth-Arrested FibroblastsMainly Membrane-AssociatedWhen HyperphosphorylatedAccumulates At Membrane RufflesColocalizes With Detyrosinated Alpha-Tubulin Along The Length Of Microtubule Bundles In Inner And Outer Pillar Cells |
| Alternative Antibody Names | Anti-Growth Arrest-Specific Protein 2 antibodyAnti-Gas-2 antibodyAnti-GAS2 antibody |
Information sourced from Uniprot.org