| Tissue Specificity | Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen. |
| Post Translational Modifications | Cleaved, during apoptosis, on a specific aspartic residue by caspases. Phosphorylated on serine residues during the G0-G1 transition phase. |
| Function | Required to maintain microtubule bundles in inner ear supporting cells, affording them with mechanical stiffness to transmit sound energy through the cochlea. |
| Protein Name | Growth Arrest-Specific Protein 2Gas-2 |
| Database Links | Reactome: R-HSA-264870 |
| Cellular Localisation | CytoplasmCytoskeletonStress FiberMembranePeripheral Membrane ProteinComponent Of The Microfilament SystemColocalizes With Actin Fibers At The Cell Border And Along The Stress Fibers In Growth-Arrested FibroblastsMainly Membrane-AssociatedWhen HyperphosphorylatedAccumulates At Membrane RufflesColocalizes With Detyrosinated Alpha-Tubulin Along The Length Of Microtubule Bundles In Inner And Outer Pillar Cells |
| Alternative Antibody Names | Anti-Growth Arrest-Specific Protein 2 antibodyAnti-Gas-2 antibodyAnti-GAS2 antibody |
Information sourced from Uniprot.org
