Function | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. |
Protein Name | Glycine--Trna LigaseDiadenosine Tetraphosphate SynthetaseAp4a SynthetaseGlycyl-Trna SynthetaseGlyrsGlycyl-Trna Synthetase 1 |
Database Links | Reactome: R-HSA-379716Reactome: R-HSA-379726 |
Cellular Localisation | CytoplasmCell ProjectionAxonSecretedExtracellular ExosomeIn Transfected Cos7 CellsNot Detected In MitochondriaNor In Golgi ApparatusSecreted By Motor NeuronPossibly Through The Exosome PathwayIsoform 1: MitochondrionIsoform 2: Cytoplasm |
Alternative Antibody Names | Anti-Glycine--Trna Ligase antibodyAnti-Diadenosine Tetraphosphate Synthetase antibodyAnti-Ap4a Synthetase antibodyAnti-Glycyl-Trna Synthetase antibodyAnti-Glyrs antibodyAnti-Glycyl-Trna Synthetase 1 antibodyAnti-GARS1 antibodyAnti-GARS antibody |
Information sourced from Uniprot.org