| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Glycine--tRNA ligase (N-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GARS1 |
| Gene ID: |
2617 |
| Uniprot ID: |
GARS_HUMAN |
| Immunogen Region: |
N-Term |
| Specificity: |
This antibody detects endogenous levels of SYG at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human N-ternal SYG |
| Function | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. |
| Protein Name | Glycine--Trna LigaseDiadenosine Tetraphosphate SynthetaseAp4a SynthetaseGlycyl-Trna SynthetaseGlyrsGlycyl-Trna Synthetase 1 |
| Database Links | Reactome: R-HSA-379716Reactome: R-HSA-379726 |
| Cellular Localisation | CytoplasmCell ProjectionAxonSecretedExtracellular ExosomeIn Transfected Cos7 CellsNot Detected In MitochondriaNor In Golgi ApparatusSecreted By Motor NeuronPossibly Through The Exosome PathwayIsoform 1: MitochondrionIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Glycine--Trna Ligase antibodyAnti-Diadenosine Tetraphosphate Synthetase antibodyAnti-Ap4a Synthetase antibodyAnti-Glycyl-Trna Synthetase antibodyAnti-Glyrs antibodyAnti-Glycyl-Trna Synthetase 1 antibodyAnti-GARS1 antibodyAnti-GARS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
