| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GAN (1-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GAN |
| Gene ID: |
8139 |
| Uniprot ID: |
GAN_HUMAN |
| Immunogen Region: |
1-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human GAN (NP_071324.1). |
| Immunogen Sequence: |
MAEGSAVSDPQHAARLLRAL SSFREESRFCDAHLVLDGEE IPVQKNILAAASPYIRTKLN YNPPKDDGSTYKIELEGISV MVMREILDYIFSGQIRLNED TIQDVVQAADLLLLTDLKTL CCEFLEGCIAAENCIGIRDF ALHYCLHHVHYLATEYLETH FRDVSSTEEFLELSPQKLKE VISLEKLNVGNERYVFEAVI RWIAHDTEIRKVHMKDVMSA LWVSGLDSSYLREQMLNEP |
| Tissue Specificity | Expressed in brain, heart and muscle. |
| Post Translational Modifications | Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. |
| Function | Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival. |
| Protein Name | GigaxoninKelch-Like Protein 16 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Gigaxonin antibodyAnti-Kelch-Like Protein 16 antibodyAnti-GAN antibodyAnti-GAN1 antibodyAnti-KLHL16 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
