Anti-GADD45GIP1 antibody (91-140 aa) (STJ92476)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human GADD45GIP1 at the amino acid range 91-140
General Information
| Short Description | Rabbit polyclonal anti-Large ribosomal subunit protein mL64 (91-140 aa) for use in IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GADD45GIP1 |
| Gene ID | 90480 |
| Uniprot ID | G45IP_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human GADD45GIP1 at the amino acid range 91-140 |
| Immunogen Region | 91-140 aa |
| Specificity | CRIF1 Polyclonal Antibody detects endogenous levels of CRIF1 protein. |
Additional Info
| Function | Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. |
| Protein Name | Large Ribosomal Subunit Protein Ml6439s Ribosomal Protein L59 - MitochondrialMrp-L59Ckii Beta-Associating ProteinCr6-Interacting Factor 1Crif1Growth Arrest And Dna Damage-Inducible Proteins-Interacting Protein 1Papillomavirus L2-Interacting Nuclear Protein 1PlinpPlinp-1P53-Responsive Gene 6 Protein |
| Database Links | Reactome: R-HSA-5368286Reactome: R-HSA-5389840Reactome: R-HSA-5419276 |
| Cellular Localisation | MitochondrionNucleusUsing N-Terminally Tagged ConstructsHas Been Found In The NucleusC-Terminally Tagged Constructs Are Targeted Exclusively To MitochondriaThis Discrepancy May Be Explained By Masking Of A Potential N-Terminal Mitochondrial Targeting Signal By The Tag |
| Alternative Antibody Names | Anti-Large Ribosomal Subunit Protein Ml64 antibodyAnti-39s Ribosomal Protein L59 - Mitochondrial antibodyAnti-Mrp-L59 antibodyAnti-Ckii Beta-Associating Protein antibodyAnti-Cr6-Interacting Factor 1 antibodyAnti-Crif1 antibodyAnti-Growth Arrest And Dna Damage-Inducible Proteins-Interacting Protein 1 antibodyAnti-Papillomavirus L2-Interacting Nuclear Protein 1 antibodyAnti-Plinp antibodyAnti-Plinp-1 antibodyAnti-P53-Responsive Gene 6 Protein antibodyAnti-GADD45GIP1 antibodyAnti-MRPL59 antibodyAnti-PLINP1 antibodyAnti-PRG6 antibody |
Information sourced from Uniprot.org