Anti-GADD34 antibody (380-400) {FITC} (STJ501135)

SKU:
STJ501135-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Bovine/Human/Monkey/Panda
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GADD34 (380-400) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.58 µg/µl
Dilution Range: WB: 1:500
DB: 1:800-1:1, 000
ELISA: 1:800-1:1, 000
IP: 1:200
IHC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PPP1R15A
Gene ID: 23645
Uniprot ID: PR15A_HUMAN
Immunogen Region: 380-400
Immunogen: Synthetic peptide corresponding to internal sequence of amino acids 380-400 of Human GADD34, covalently modified and coupled to a carrier protein.
Post Translational Modifications Phosphorylated at multiple Ser/Thr residues. Phosphorylated on tyrosine by LYN.which impairs its antiproliferative activity. Phosphorylation at Tyr-262 enhances proteasomal degradation, this position is dephosphorylated by PTPN2. Polyubiquitinated. Exhibits a rapid proteasomal degradation with a half-life under 1 hour, ubiquitination depends on endoplasmic reticulum association.
Function Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing p53/TP53 phosphorylation on 'Ser-15'. Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux. Acts also a viral restriction factor by attenuating HIV-1 replication. Mechanistically, mediates the inhibition of HIV-1 TAR RNA-mediated translation. (Microbial infection) Promotes enterovirus 71 replication by mediating the internal ribosome entry site (IRES) activity of viral 5'-UTR.
Protein Name Protein Phosphatase 1 Regulatory Subunit 15a
Growth Arrest And Dna Damage-Inducible Protein Gadd34
Myeloid Differentiation Primary Response Protein Myd116 Homolog
Database Links Reactome: R-HSA-2173788
Reactome: R-HSA-9648895
Cellular Localisation Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Mitochondrion Outer Membrane
Associates With Membranes Via An N-Terminal Amphipathic Intramembrane Region
Alternative Antibody Names Anti-Protein Phosphatase 1 Regulatory Subunit 15a antibody
Anti-Growth Arrest And Dna Damage-Inducible Protein Gadd34 antibody
Anti-Myeloid Differentiation Primary Response Protein Myd116 Homolog antibody
Anti-PPP1R15A antibody
Anti-GADD34 antibody

Information sourced from Uniprot.org

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