• Western blot analysis of 1) Mouse Brain Tissue, 2) Rat Brain Tissue with GABA A Receptor α4 Rabbit pAb diluted at 1:2,000.
  • Immunohistochemical analysis of paraffin-embedded Rat BrainTissue using GABA A Receptor α4 Rabbit pAb diluted at 1:200.
  • Immunohistochemical analysis of paraffin-embedded mouse BrainTissue using GABA A Receptor α4 Rabbit pAb diluted at 1:200.

Anti-GABRA4 antibody (149-199 aa) (STJ197387)

SKU:
STJ197387

£48.00 - £252.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Gamma-aminobutyric acid receptor subunit alpha-4 receptor subunit alpha-4 (149-199 aa) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
IHC 1:100-200
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GABRA4
Gene ID: 2557
Uniprot ID: GBRA4_HUMAN
Immunogen Region: 149-199 aa
Specificity: GABA A Receptor Alpha 4 protein (A226) detects endogenous levels of GABA A Receptor Alpha 4
Immunogen: Synthetic peptide derived from GABA A Receptor Alpha 4 at the amino acid range 149-199
Function Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. GABAARs containing alpha-4 are predominantly extrasynaptic, contributing to tonic inhibition in dentate granule cells and thalamic relay neurons. Extrasynaptic alpha-4-containing GABAARs control levels of excitability and network activity. GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness.
Protein Name Gamma-Aminobutyric Acid Receptor Subunit Alpha-4
Gaba(A Receptor Subunit Alpha-4
Gabaar Subunit Alpha-4
Database Links Reactome: R-HSA-977443
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Postsynaptic Cell Membrane
Alternative Antibody Names Anti-Gamma-Aminobutyric Acid Receptor Subunit Alpha-4 antibody
Anti-Gaba(A Receptor Subunit Alpha-4 antibody
Anti-Gabaar Subunit Alpha-4 antibody
Anti-GABRA4 antibody

Information sourced from Uniprot.org

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