• Immunolabeling of mouse globus pallidus externus (subcortical structure) labelling the Alpha 1-subunit of the GABAA Receptor (STJA0003639, DAB, 1:100). Images courtesy Dr. Anton Reiner, University of Tennessee Health Science Center (Memphis, TN).
  • Western blot of mouse forebrain lysates from wild type (WT) and Alpha 1-knockout (K/O) animals showing specific immunolabeling of the ~51 kDa Alpha 1-subunit of the GABAA-R. The labeling was absent from a lysate prepared from Alpha 1-knockout animals.
  • Immunolabeling of mouse substantia nigra (mid brain) labelling the Alpha 1-subunit of the GABAA Receptor (STJA0003639, DAB, 1:100). Images courtesy Dr. Anton Reiner, University of Tennessee Health Science Center (Memphis, TN).
  • Immunolabeling of mouse deep cerebellar nucleas labelling the Alpha 1-subunit of the GABAA Receptor (STJA0003639, DAB, 1:100). Images courtesy Dr. Anton Reiner, University of Tennessee Health Science Center (Memphis, TN).

Anti-GABRA1 antibody (Cytoplasmic Loop) (STJA0003639)

SKU:
STJA0003639-100

£442.50
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Host: Rabbit
Applications: WB/IHC
Reactivity: Mouse/Rat/Bovine/Canine/Human/Non-Human Primates
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GABAA Receptor a 1 (Cytoplasmic Loop) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from serum.
Dilution Range: WB 1:1000
IHC 1:100
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Gabra1
Gene ID: 29705
Uniprot ID: GBRA1_RAT
Immunogen Region: Cytoplasmic Loop
Immunogen: Fusion protein from the cytoplasmic loop of the alpha 1 subunit.
Tissue Specificity Expressed in brain (at protein level).
Post Translational Modifications Glycosylated.
Function Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity. GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection. Functions also as histamine receptor and mediates cellular responses to histamine.
Protein Name Gamma-Aminobutyric Acid Receptor Subunit Alpha-1
Gaba(A Receptor Subunit Alpha-1
Database Links Reactome: R-RNO-977443
Cellular Localisation Postsynaptic Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Cytoplasmic Vesicle Membrane
Alternative Antibody Names Anti-Gamma-Aminobutyric Acid Receptor Subunit Alpha-1 antibody
Anti-Gaba(A Receptor Subunit Alpha-1 antibody
Anti-Gabra1 antibody
Anti-Gabra-1 antibody

Information sourced from Uniprot.org

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