| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GABRA1 (28-251) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GABRA1 |
| Gene ID: |
2554 |
| Uniprot ID: |
GBRA1_HUMAN |
| Immunogen Region: |
28-251 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 28-251 of human GABRA1 (NP_000797.2). |
| Immunogen Sequence: |
QPSLQDELKDNTTVFTRILD RLLDGYDNRLRPGLGERVTE VKTDIFVTSFGPVSDHDMEY TIDVFFRQSWKDERLKFKGP MTVLRLNNLMASKIWTPDTF FHNGKKSVAHNMTMPNKLLR ITEDGTLLYTMRLTVRAECP MHLEDFPMDAHACPLKFGSY AYTRAEVVYEWTREPARSVV VAEDGSRLNQYDLLGQTVDS GIVQSSTGEYVVMTTHFHLK RKIG |
| Post Translational Modifications | Glycosylated. |
| Function | Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity. GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection. Functions also as histamine receptor and mediates cellular responses to histamine. |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit Alpha-1Gaba(A Receptor Subunit Alpha-1 |
| Database Links | Reactome: R-HSA-1236394Reactome: R-HSA-977443 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmic Vesicle Membrane |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Alpha-1 antibodyAnti-Gaba(A Receptor Subunit Alpha-1 antibodyAnti-GABRA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
