Anti-GABA Transporter/GAT 1 antibody (C-Term) (STJA0003654)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.
General Information
| Short Description | Rabbit polyclonal anti-GABA Transporter/GAT 1 (C-Term) for use in WB and IHC in Human, Mouse, Non-Human Primates and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Non-Human Primates/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | This antibody was antigen affinity purified from serum. |
| Dilution Range | WB 1:1000IHC 1:100-1:1000 |
| Formulation | 100 ยตl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 ยตg per ml BSA and 50% Glycerol. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Slc6a1 |
| Gene ID | 79212 |
| Uniprot ID | SC6A1_RAT |
| Immunogen | Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH. |
| Immunogen Region | C-Term |
Additional Info
| Tissue Specificity | Brain. |
| Function | Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse. The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA. The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA. Also mediates sodium- and chloride-dependent transport of hypotaurine. |
| Protein Name | Sodium- And Chloride-Dependent Gaba Transporter 1Gat-1Solute Carrier Family 6 Member 1 |
| Database Links | Reactome: R-RNO-442660Reactome: -RNO-888593 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPresynapseLocalized At The Presynaptic Terminals Of Interneurons |
| Alternative Antibody Names | Anti-Sodium- And Chloride-Dependent Gaba Transporter 1 antibodyAnti-Gat-1 antibodyAnti-Solute Carrier Family 6 Member 1 antibodyAnti-Slc6a1 antibodyAnti-Gabt1 antibodyAnti-Gat-1 antibodyAnti-Gat1 antibody |
Information sourced from Uniprot.org