• Western blot of rat hippocampal lysate showing specific immunolabeling of the ~67 kDa GAT-1 protein.
  • Immunoflouresence of mouse retina specifically labeling GAT-1 protein (STJA0003654, red, 1:500) in the inner plexiform layer (IPL). The white identifies nuclei stained with DAPI. The retina was fixed with 4% paraformaldehyde for 30 minutes, embedded in 5% agarose, and sliced into 60 micron thick slices with a vibratome. The image is a Z-stack taken from a confocal microscope. Image courtesy of Andrea Wellington, Assistant Research Scientist, University of Arizona Physiology Dept.

Anti-GABA Transporter/GAT 1 antibody (C-Term) (STJA0003654)

SKU:
STJA0003654-100

£454.50
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Non-Human Primates/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GABA Transporter/GAT 1 (C-Term) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from serum.
Dilution Range: WB 1:1000
IHC 1:100-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Slc6a1
Gene ID: 79212
Uniprot ID: SC6A1_RAT
Immunogen Region: C-Term
Immunogen: Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.
Tissue Specificity Brain.
Function Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse. The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA. The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA. Also mediates sodium- and chloride-dependent transport of hypotaurine.
Protein Name Sodium- And Chloride-Dependent Gaba Transporter 1
Gat-1
Solute Carrier Family 6 Member 1
Database Links Reactome: R-RNO-442660
Reactome: -RNO-888593
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Presynapse
Localized At The Presynaptic Terminals Of Interneurons
Alternative Antibody Names Anti-Sodium- And Chloride-Dependent Gaba Transporter 1 antibody
Anti-Gat-1 antibody
Anti-Solute Carrier Family 6 Member 1 antibody
Anti-Slc6a1 antibody
Anti-Gabt1 antibody
Anti-Gat-1 antibody
Anti-Gat1 antibody

Information sourced from Uniprot.org

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