| Function | Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. GABAARs containing alpha-5/GABRA5 subunits are mainly extrasynaptic and contribute to the tonic GABAergic inhibition in the hippocampus. Extrasynaptic alpha-5-containing GABAARs in CA1 pyramidal neurons play a role in learning and memory processes. |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit Alpha-5Gaba(A Receptor Subunit Alpha-5Gabaar Subunit Alpha-5 |
| Database Links | Reactome: R-HSA-977443 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Alpha-5 antibodyAnti-Gaba(A Receptor Subunit Alpha-5 antibodyAnti-Gabaar Subunit Alpha-5 antibodyAnti-GABRA5 antibody |
Information sourced from Uniprot.org
