Anti-GABA A Receptor alpha 1 antibody [R05-6H-4] (STJA0033725)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenPeptide
General Information
| Short Description | Rabbit monoclonal anti-GABA A Receptor alpha 1 for use in WB and IHC-P in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R05-6H-4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A purified |
| Dilution Range | WB 1:500-1:2000IHC-P 1:50-1:100 |
| Formulation | Liquid in PBS, Glycerol and BSA |
| Storage Instruction | Store at-20°C. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | Gabra1 |
| Gene ID | 14394 |
| Uniprot ID | GBRA1_MOUSE |
| Immunogen | Peptide |
Additional Info
| Tissue Specificity | Expressed in the cerebellum. |
| Post Translational Modifications | Glycosylated. |
| Function | Alpha subunit of the heteropentameric ligand-gated chloride channel gated by Gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Alpha-1/GABRA1-containing GABAARs are largely synaptic. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity.the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation. GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response. GABAARs containing alpha, beta and epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings. Alpha-1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection. Together with rho subunits, may also control neuronal and glial GABAergic transmission in the cerebellum. |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit Alpha-1Gaba(A Receptor Subunit Alpha-1Gabaar Subunit Alpha-1 |
| Database Links | Reactome: R-MMU-977443 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmic Vesicle MembraneLocated At The Plasma Membrane Of AstrocytesLocated In The SomaticProximal And Distal Dendritic Regions Of Cerebellar Purkinje Cells And In The Molecular Layer |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Alpha-1 antibodyAnti-Gaba(A Receptor Subunit Alpha-1 antibodyAnti-Gabaar Subunit Alpha-1 antibodyAnti-Gabra1 antibodyAnti-Gabra-1 antibody |
Information sourced from Uniprot.org