• STJ71161 (0. 5µg/ml) staining of K562 cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-GAB2 antibody (Internal) (STJ71161)

SKU:
STJ71161-100

£312.50
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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Rat/Dog
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-GAB2 (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: Peptide ELISA: antibody detection limit dilution 1:64000.
WB: Approx 80kDa band observed in lysates of cell line K562 (calculated MW of 74.5kDa according to NP_536739.1). Recommended concentration: 0.5-1.5µg/ml.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: GAB2
Gene ID: 9846
Uniprot ID: GAB2_HUMAN
Immunogen Region: Internal
Accession Number: NP_536739.1; NP_036428.1
Specificity: This antibody is expected to recognize both reported isoforms (NP_536739.1; NP_036428.1).
Immunogen Sequence: QVDKEKTQALQN
Function Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Protein Name Grb2-Associated-Binding Protein 2
Grb2-Associated Binder 2
Growth Factor Receptor Bound Protein 2-Associated Protein 2
Pp100
Database Links Reactome: R-HSA-109704
Reactome: R-HSA-1257604
Reactome: R-HSA-1433557
Reactome: R-HSA-1839117
Reactome: R-HSA-2219530
Reactome: R-HSA-2730905
Reactome: R-HSA-6811558
Reactome: R-HSA-8853659
Reactome: R-HSA-8983432
Reactome: R-HSA-912526
Reactome: R-HSA-9607240
Reactome: R-HSA-9645135
Reactome: R-HSA-9674555
Reactome: R-HSA-9680350
Reactome: R-HSA-9702518
Reactome: R-HSA-9703465
Reactome: R-HSA-9703648
Cellular Localisation Cytoplasm
Cell Membrane
Membrane Raft
Alternative Antibody Names Anti-Grb2-Associated-Binding Protein 2 antibody
Anti-Grb2-Associated Binder 2 antibody
Anti-Growth Factor Receptor Bound Protein 2-Associated Protein 2 antibody
Anti-Pp100 antibody
Anti-GAB2 antibody
Anti-KIAA0571 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance