• Western blot analysis of various lysates using GAA Rabbit monoclonal antibody (STJ11102966) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-GAA antibody (100-200) [S6MR] (STJ11102966)

SKU:
STJ11102966

£146.50 - £639.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-GAA (100-200) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S6MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GAA
Gene ID: 2548
Uniprot ID: LYAG_HUMAN
Immunogen Region: 100-200
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human GAA (P10253).
Immunogen Sequence: QEQCEARGCCYIPAKQGLQG AQMGQPWCFFPPSYPSYKLE NLSSSEMGYTATLTRTTPTF FPKDILTLRLDVMMETENRL HFTIKDPANRRYEVPLETPH V
Post Translational Modifications The different forms of acid glucosidase are obtained by proteolytic processing. Phosphorylation of mannose residues ensures efficient transport of the enzyme to the lysosomes via the mannose 6-phosphate receptor.
Function Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans.
Protein Name Lysosomal Alpha-Glucosidase
Acid Maltase
Aglucosidase Alfa Cleaved Into - 76 Kda Lysosomal Alpha-Glucosidase - 70 Kda Lysosomal Alpha-Glucosidase
Database Links Reactome: R-HSA-5357609
Reactome: R-HSA-6798695
Reactome: R-HSA-70221
Cellular Localisation Lysosome
Lysosome Membrane
Alternative Antibody Names Anti-Lysosomal Alpha-Glucosidase antibody
Anti-Acid Maltase antibody
Anti-Aglucosidase Alfa Cleaved Into - 76 Kda Lysosomal Alpha-Glucosidase - 70 Kda Lysosomal Alpha-Glucosidase antibody
Anti-GAA antibody

Information sourced from Uniprot.org

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