Anti-FYB1 antibody (STJ98493)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
ImmunogenPurified recombinant human Fyb protein fragments expressed in E.coli.
General Information
| Short Description | Mouse monoclonal anti-FYN-binding protein 1 for use in WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Mouse |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity purification |
| Dilution Range | WB 1:1000-1:2000 |
| Formulation | Liquid in 0.1M Tris-Glycine (pH7.4, 150 mM NaCl) , 0.2% Sodium Azide and 50% Glycerol. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FYB1 |
| Gene ID | 2533 |
| Uniprot ID | FYB1_HUMAN |
| Immunogen | Purified recombinant human Fyb protein fragments expressed in E.coli. |
| Specificity | Fyb Monoclonal Antibody detects endogenous levels of Fyb protein. |
Additional Info
| Post Translational Modifications | T-cell receptor ligation leads to increased tyrosine phosphorylation. |
| Function | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. Modulates the expression of IL2. Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. |
| Protein Name | Fyn-Binding Protein 1Adhesion And Degranulation Promoting Adaptor ProteinAdapFyb-120/130P120/P130Fyn-T-Binding ProteinSlap-130Slp-76-Associated Phosphoprotein |
| Database Links | Reactome: R-HSA-202433Reactome: R-HSA-391160 |
| Cellular Localisation | CytoplasmNucleusCell JunctionColocalizes With Tmem47 At Cell-Cell Contacts In Podocytes |
| Alternative Antibody Names | Anti-Fyn-Binding Protein 1 antibodyAnti-Adhesion And Degranulation Promoting Adaptor Protein antibodyAnti-Adap antibodyAnti-Fyb-120/130 antibodyAnti-P120/P130 antibodyAnti-Fyn-T-Binding Protein antibodyAnti-Slap-130 antibodyAnti-Slp-76-Associated Phosphoprotein antibodyAnti-FYB1 antibodyAnti-FYB antibodyAnti-SLAP130 antibody |
Information sourced from Uniprot.org