Anti-FXYD5/Dysadherin antibody (ECD) [M031] (STJA0041225)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenClone (M031) was generated from a proprietary antigen related to the native human FXYD5 protein expressed in MDA-MB-231 breast cancer cell line.
General Information
| Short Description | Mouse monoclonal anti-FXYD5/Dysadherin (ECD) for use in ELISA, WB, ICC and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IP |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | M031 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Protein G Purified |
| Dilution Range | WB 1:500ICC 1:100IP 1:50 |
| Formulation | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Storage Instruction | Storage at-20ยฐC is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at-20ยฐC. |
Target Information
| Gene Symbol | FXYD5 |
| Gene ID | 53827 |
| Uniprot ID | FXYD5_HUMAN |
| Immunogen | Clone (M031) was generated from a proprietary antigen related to the native human FXYD5 protein expressed in MDA-MB-231 breast cancer cell line. |
| Immunogen Region | ECD |
| Immunogen Sequence | Human |
| Specificity | Clone M031 mouse monoclonal antibody detects a 35-55 kDa* band on SDS-PAGE immunoblots of human A431, A549, MeWo, MDA-MB-231 cell, as well as human breast, lung, and skin tissues. The antibody works for western blot, immunoprecipitation, ELISA, and i |
Additional Info
| Post Translational Modifications | Glycosylated. |
| Function | Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. May increase NKA activity by increasing the apparent affinity for Na(+). Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. |
| Protein Name | Fxyd Domain-Containing Ion Transport Regulator 5Dysadherin |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinBasolateral Cell MembraneIn Kidneys Localizes To The Basolateral Membrane Of The Connecting Tubule |
| Alternative Antibody Names | Anti-Fxyd Domain-Containing Ion Transport Regulator 5 antibodyAnti-Dysadherin antibodyAnti-FXYD5 antibodyAnti-DYSAD antibodyAnti-IWU1 antibodyAnti-HSPC113 antibodyAnti-UNQ2561 antibodyAnti-PRO6241 antibody |
Information sourced from Uniprot.org