Anti-FXR2 antibody (550-650) (STJ116027)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FXR2 (550-650) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FXR2 |
| Gene ID | 9513 |
| Uniprot ID | FXR2_HUMAN |
| Immunogen Region | 550-650 |
| Immunogen Sequence | RRRTDEDRTVMDGGLESDGP NMTENGLEDESRPQRRNRSR RRRNRGNRTDGSISGDRQPV TVADYISRAESQSRQRPPLE RTKPSEDSLSGQKGDSVSKL P |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 550-650 of human FXR2 (NP_004851.2). |
Additional Info
| Tissue Specificity | Expressed in all tissues examined including heart, brain, kidney and testis. In brain, present at high level in neurons and especially in the Purkinje cells at the interface between the granular layer and the molecular layer (at protein level). |
| Function | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis. Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability. Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus. |
| Protein Name | Rna-Binding Protein Fxr2Fxr2pFmr1 Autosomal Homolog 2 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoplasmic Ribonucleoprotein GranulePostsynapseSpecifically Localizes To Cytoplasmic Ribonucleoprotein Membraneless CompartmentsLocalization To The Post-Synaptic Region Is Dependent On Fmr1 |
| Alternative Antibody Names | Anti-Rna-Binding Protein Fxr2 antibodyAnti-Fxr2p antibodyAnti-Fmr1 Autosomal Homolog 2 antibodyAnti-FXR2 antibodyAnti-FMR1L2 antibody |
Information sourced from Uniprot.org