| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylation at Ser-39 inhibits actin-binding. Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF. |
| Function | Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF. |
| Protein Name | Fascin55 Kda Actin-Bundling ProteinSinged-Like ProteinP55 |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | CytoplasmCytosolCell CortexCytoskeletonStress FiberCell ProjectionFilopodiumInvadopodiumMicrovillusCell JunctionColocalized With Rufy3 And F-Actin At Filipodia Of The Axonal Growth ConeColocalized With Dbn1 And F-Actin At The Transitional Domain Of The Axonal Growth Cone |
| Alternative Antibody Names | Anti-Fascin antibodyAnti-55 Kda Actin-Bundling Protein antibodyAnti-Singed-Like Protein antibodyAnti-P55 antibodyAnti-FSCN1 antibodyAnti-FAN1 antibodyAnti-HSN antibodyAnti-SNL antibody |
Information sourced from Uniprot.org
![Immunofluorescence analysis of NIH-3T3 cells using [KO Validated] Fascin/Fascin/FSCN1 Rabbit polyclonal antibody (STJ23712) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/99661/384925/STJ23712_1__28840.1713153730.jpg?c=1 "Immunofluorescence analysis of NIH-3T3 cells using [KO Validated] Fascin/Fascin/FSCN1 Rabbit polyclonal antibody (STJ23712) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.")
![Immunofluorescence analysis of C6 cells using [KO Validated] Fascin/Fascin/FSCN1 Rabbit polyclonal antibody (STJ23712) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/99661/384926/STJ23712_2__22318.1713153730.jpg?c=1 "Immunofluorescence analysis of C6 cells using [KO Validated] Fascin/Fascin/FSCN1 Rabbit polyclonal antibody (STJ23712) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.")
![Immunohistochemistry analysis of paraffin-embedded mouse testis using [KO Validated] Fascin/FSCN1 Rabbit polyclonal antibody (STJ23712) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/99661/384927/STJ23712_3__29681.1713153731.jpg?c=1 "Immunohistochemistry analysis of paraffin-embedded mouse testis using [KO Validated] Fascin/FSCN1 Rabbit polyclonal antibody (STJ23712) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.")
![Immunofluorescence analysis of NIH-3T3 cells using [KO Validated] Fascin/Fascin/FSCN1 Rabbit polyclonal antibody (STJ23712) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/99661/384925/STJ23712_1__28840.1713153730.jpg?c=1 "Immunofluorescence analysis of NIH-3T3 cells using [KO Validated] Fascin/Fascin/FSCN1 Rabbit polyclonal antibody (STJ23712) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.")
