| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | FRS2 |
| Gene ID: | 10818 |
| Uniprot ID: | FRS2_HUMAN |
| Immunogen Region: | 200-470 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-470 of human FRS2 (NP_006645.3). |
| Immunogen Sequence: | TGVQEERKNRTSVHVPLEAR VSNAESSTPKEEPSSIEDRD PQILLEPEGVKFVLGPTPVQ KQLMEKEKLEQLGRDQVSGS GANNTEWDTGYDSDERRDAP SVNKLVYENINGLSIPSASG VRRGRLTSTSTSDTQNINNS AQRRTALLNYENLPSLPPVW EARKLSRDEDDNLGPKTPSL NGYHNNLDPMHNYVNTENVT VPASAHKIEYSRRRDCTPTV FNFDIRRPSLEHRQLNYIQ |
| Tissue Specificity | Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. |
| Post Translational Modifications | Phosphorylated by ULK2 in vitro. Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases.this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases. Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination. |
| Function | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. |
| Protein Name | Fibroblast Growth Factor Receptor Substrate 2Fgfr Substrate 2Fgfr-Signaling Adaptor SntSuc1-Associated Neurotrophic Factor Target 1Snt-1 |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1257604Reactome: R-HSA-170968Reactome: R-HSA-201556Reactome: R-HSA-2219530Reactome: R-HSA-5654689Reactome: R-HSA-5654693Reactome: R-HSA-5654695Reactome: R-HSA-5654700Reactome: R-HSA-5654706Reactome: R-HSA-5654710Reactome: R-HSA-5654712Reactome: R-HSA-5654720Reactome: R-HSA-5654726Reactome: R-HSA-5654727Reactome: R-HSA-5654732Reactome: R-HSA-5654733Reactome: R-HSA-5655253Reactome: R-HSA-5655291Reactome: R-HSA-5655302Reactome: R-HSA-5655332Reactome: R-HSA-5673001Reactome: R-HSA-6811558Reactome: R-HSA-8853659Reactome: R-HSA-9028731Reactome: R-HSA-9696270Reactome: R-HSA-9696273Reactome: R-HSA-9725370 |
| Cellular Localisation | Endomembrane SystemCytoplasmicMembrane-Bound |
| Alternative Antibody Names | Anti-Fibroblast Growth Factor Receptor Substrate 2 antibodyAnti-Fgfr Substrate 2 antibodyAnti-Fgfr-Signaling Adaptor Snt antibodyAnti-Suc1-Associated Neurotrophic Factor Target 1 antibodyAnti-Snt-1 antibodyAnti-FRS2 antibody |
Information sourced from Uniprot.org