| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | FRS2 |
| Gene ID: | 10818 |
| Uniprot ID: | FRS2_HUMAN |
| Immunogen Region: | 200-470 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-470 of human FRS2 (NP_006645.3). |
| Immunogen Sequence: | TGVQEERKNRTSVHVPLEAR VSNAESSTPKEEPSSIEDRD PQILLEPEGVKFVLGPTPVQ KQLMEKEKLEQLGRDQVSGS GANNTEWDTGYDSDERRDAP SVNKLVYENINGLSIPSASG VRRGRLTSTSTSDTQNINNS AQRRTALLNYENLPSLPPVW EARKLSRDEDDNLGPKTPSL NGYHNNLDPMHNYVNTENVT VPASAHKIEYSRRRDCTPTV FNFDIRRPSLEHRQLNYIQ |
| Tissue Specificity | Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. |
| Post Translational Modifications | Phosphorylated by ULK2 in vitro. Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases.this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases. Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination. |
| Function | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. |
| Protein Name | Fibroblast Growth Factor Receptor Substrate 2 Fgfr Substrate 2 Fgfr-Signaling Adaptor Snt Suc1-Associated Neurotrophic Factor Target 1 Snt-1 |
| Database Links | Reactome: R-HSA-109704 Reactome: R-HSA-1257604 Reactome: R-HSA-170968 Reactome: R-HSA-201556 Reactome: R-HSA-2219530 Reactome: R-HSA-5654689 Reactome: R-HSA-5654693 Reactome: R-HSA-5654695 Reactome: R-HSA-5654700 Reactome: R-HSA-5654706 Reactome: R-HSA-5654710 Reactome: R-HSA-5654712 Reactome: R-HSA-5654720 Reactome: R-HSA-5654726 Reactome: R-HSA-5654727 Reactome: R-HSA-5654732 Reactome: R-HSA-5654733 Reactome: R-HSA-5655253 Reactome: R-HSA-5655291 Reactome: R-HSA-5655302 Reactome: R-HSA-5655332 Reactome: R-HSA-5673001 Reactome: R-HSA-6811558 Reactome: R-HSA-8853659 Reactome: R-HSA-9028731 Reactome: R-HSA-9696270 Reactome: R-HSA-9696273 Reactome: R-HSA-9725370 |
| Cellular Localisation | Endomembrane System Cytoplasmic Membrane-Bound |
| Alternative Antibody Names | Anti-Fibroblast Growth Factor Receptor Substrate 2 antibody Anti-Fgfr Substrate 2 antibody Anti-Fgfr-Signaling Adaptor Snt antibody Anti-Suc1-Associated Neurotrophic Factor Target 1 antibody Anti-Snt-1 antibody Anti-FRS2 antibody |
Information sourced from Uniprot.org