| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FPR2 (2-50 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
FPR2 |
| Gene ID: |
2358 |
| Uniprot ID: |
FPR2_HUMAN |
| Immunogen Region: |
2-50 aa |
| Specificity: |
Specific for FPR2. |
| Immunogen: |
A synthetic peptide from aa region 2-50 of human FPR2 conjugated to blue carrier protein was used as the antigen. |
| Function | Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of pro-inflammatory signals such as LTB4 (leukotriene B4). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation. Acts as a receptor for humanin. |
| Protein Name | N-Formyl Peptide Receptor 2Fmlp-Related Receptor IFmlp-R-IFormyl Peptide Receptor-Like 1Hm63Lipoxin A4 ReceptorLxa4 ReceptorRfp |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-418594Reactome: R-HSA-444473Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinAssociates With Amyloid-Beta Protein 42Product Of AppAt The Cell Surface And The Complex Is Then Rapidly InternalizedAlso Internalized In The Presence Of Humanin |
| Alternative Antibody Names | Anti-N-Formyl Peptide Receptor 2 antibodyAnti-Fmlp-Related Receptor I antibodyAnti-Fmlp-R-I antibodyAnti-Formyl Peptide Receptor-Like 1 antibodyAnti-Hm63 antibodyAnti-Lipoxin A4 Receptor antibodyAnti-Lxa4 Receptor antibodyAnti-Rfp antibodyAnti-FPR2 antibodyAnti-FPRH1 antibodyAnti-FPRL1 antibodyAnti-LXA4R antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
