| Function | Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. |
| Protein Name | Folylpolyglutamate Synthase - MitochondrialFolylpoly-Gamma-Glutamate SynthetaseFpgsTetrahydrofolylpolyglutamate SynthaseTetrahydrofolate Synthase |
| Database Links | Reactome: R-HSA-196757 |
| Cellular Localisation | Isoform 1: Mitochondrion Inner MembraneMitochondrion MatrixIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Folylpolyglutamate Synthase - Mitochondrial antibodyAnti-Folylpoly-Gamma-Glutamate Synthetase antibodyAnti-Fpgs antibodyAnti-Tetrahydrofolylpolyglutamate Synthase antibodyAnti-Tetrahydrofolate Synthase antibodyAnti-FPGS antibody |
Information sourced from Uniprot.org
