| Tissue Specificity | Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis. |
| Post Translational Modifications | Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators. |
| Function | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Also plays a role in DNA break repair, participating in the DNA damage checkpoint response. Promotes transcription of PHB2. |
| Protein Name | Forkhead Box Protein M1Forkhead-Related Protein Fkhl16Hepatocyte Nuclear Factor 3 Forkhead Homolog 11Hfh-11Hnf-3/Fork-Head Homolog 11M-Phase Phosphoprotein 2Mpm-2 Reactive Phosphoprotein 2Transcription Factor TridentWinged-Helix Factor From Ins-1 Cells |
| Database Links | Reactome: R-HSA-156711Reactome: R-HSA-69273Reactome: R-HSA-9725371 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Forkhead Box Protein M1 antibodyAnti-Forkhead-Related Protein Fkhl16 antibodyAnti-Hepatocyte Nuclear Factor 3 Forkhead Homolog 11 antibodyAnti-Hfh-11 antibodyAnti-Hnf-3/Fork-Head Homolog 11 antibodyAnti-M-Phase Phosphoprotein 2 antibodyAnti-Mpm-2 Reactive Phosphoprotein 2 antibodyAnti-Transcription Factor Trident antibodyAnti-Winged-Helix Factor From Ins-1 Cells antibodyAnti-FOXM1 antibodyAnti-FKHL16 antibodyAnti-HFH11 antibodyAnti-MPP2 antibodyAnti-WIN antibody |
Information sourced from Uniprot.org
