| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | FOXH1 |
| Gene ID: | 8928 |
| Uniprot ID: | FOXH1_HUMAN |
| Immunogen Region: | 1-270 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human FOXH1 (NP_003914.1). |
| Immunogen Sequence: | MGPCSGSRLGPPEAESPSQP PKRRKKRYLRHDKPPYTYLA MIALVIQAAPSRRLKLAQII RQVQAVFPFFREDYEGWKDS IRHNLSSNRCFRKVPKDPAK PQAKGNFWAVDVSLIPAEAL RLQNTALCRRWQNGGARGAF AKDLGPYVLHGRPYRPPSPP PPPSEGFSIKSLLGGSGEGA PWPGLAPQSSPVPAGTGNSG EEAVPTPPLPSSERPLWPLC PLPGPTRVEGETVQGGAIG |
| Tissue Specificity | Ubiquitous. |
| Function | Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGTGTGTATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). |
| Protein Name | Forkhead Box Protein H1Forkhead Activin Signal Transducer 1Fast-1Hfast-1Forkhead Activin Signal Transducer 2Fast-2 |
| Database Links | Reactome: R-HSA-1181150Reactome: R-HSA-1502540Reactome: R-HSA-9754189Reactome: R-HSA-9796292 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Forkhead Box Protein H1 antibodyAnti-Forkhead Activin Signal Transducer 1 antibodyAnti-Fast-1 antibodyAnti-Hfast-1 antibodyAnti-Forkhead Activin Signal Transducer 2 antibodyAnti-Fast-2 antibodyAnti-FOXH1 antibodyAnti-FAST1 antibodyAnti-FAST2 antibody |
Information sourced from Uniprot.org
