• Western blot analysis of the lysates from HepG2 cells using FOLR1 antibody.
  • Western blot analysis of lysates from K562, LOVO, and HUVEC cells, using FOLR1 Antibody. The lane on the right is blocked with the synthesized peptide.

Anti-FOLR1 antibody (41-90 aa) (STJ93159)

SKU:
STJ93159

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Folate receptor alpha (41-90 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FOLR1
Gene ID: 2348
Uniprot ID: FOLR1_HUMAN
Immunogen Region: 41-90 aa
Specificity: FR-Alpha Polyclonal Antibody detects endogenous levels of FR-Alpha protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human FOLR1 at the amino acid range 41-90
Post Translational Modifications The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.
Protein Name Folate Receptor Alpha
Fr-Alpha
Adult Folate-Binding Protein
Fbp
Folate Receptor 1
Folate Receptor - Adult
Kb Cells Fbp
Ovarian Tumor-Associated Antigen Mov18
Database Links Reactome: R-HSA-204005
Reactome: R-HSA-5694530
Reactome: R-HSA-6807878
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Apical Cell Membrane
Basolateral Cell Membrane
Gpi-Like-Anchor
Secreted
Cytoplasmic Vesicle
Clathrin-Coated Vesicle
Endosome
Endocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane
Alternative Antibody Names Anti-Folate Receptor Alpha antibody
Anti-Fr-Alpha antibody
Anti-Adult Folate-Binding Protein antibody
Anti-Fbp antibody
Anti-Folate Receptor 1 antibody
Anti-Folate Receptor - Adult antibody
Anti-Kb Cells Fbp antibody
Anti-Ovarian Tumor-Associated Antigen Mov18 antibody
Anti-FOLR1 antibody
Anti-FOLR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance