| Host: |
Rabbit |
| Applications: |
ELISA/IHC/IP/WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FOLR1 (200-250) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: |
Affinity Purified |
| Concentration: |
0.5 µg/µl |
| Dilution Range: |
WB: 1:500ELISA: 1:50, 000IP: 1:200IHC: 1:50-1:150IF: 1:50-1:150 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Folr1 |
| Gene ID: |
14275 |
| Uniprot ID: |
FOLR1_MOUSE |
| Immunogen Region: |
200-250 |
| Immunogen: |
Synthetic peptide taken within amino acid region 200-250 on mouse Folate receptor alpha protein. |
| Tissue Specificity | Detected in kidney proximal tubules (at protein level). |
| Post Translational Modifications | The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption. |
| Protein Name | Folate Receptor AlphaFr-AlphaFolate Receptor 1Folate-Binding Protein 1 |
| Database Links | Reactome: R-MMU-204005Reactome: -MMU-5694530Reactome: -MMU-6807878 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorApical Cell MembraneBasolateral Cell MembraneGpi-Like-AnchorSecretedCytoplasmic VesicleClathrin-Coated VesicleEndosomeEndocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane |
| Alternative Antibody Names | Anti-Folate Receptor Alpha antibodyAnti-Fr-Alpha antibodyAnti-Folate Receptor 1 antibodyAnti-Folate-Binding Protein 1 antibodyAnti-Folr1 antibodyAnti-Fbp1 antibodyAnti-Folbp1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
