• Immunohistochemistry of mouse kidney with Anti-FOLR1 primary antibody (STJ501070) at 1:50 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 20X.

Anti-FOLR1 antibody (200-250) (STJ501070)

SKU:
STJ501070-100

£441.50
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FOLR1 (200-250) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:50, 000
IP: 1:200
IHC: 1:50-1:150
IF: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Folr1
Gene ID: 14275
Uniprot ID: FOLR1_MOUSE
Immunogen Region: 200-250
Immunogen: Synthetic peptide taken within amino acid region 200-250 on mouse Folate receptor alpha protein.
Tissue Specificity Detected in kidney proximal tubules (at protein level).
Post Translational Modifications The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption.
Protein Name Folate Receptor Alpha
Fr-Alpha
Folate Receptor 1
Folate-Binding Protein 1
Database Links Reactome: R-MMU-204005
Reactome: -MMU-5694530
Reactome: -MMU-6807878
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Apical Cell Membrane
Basolateral Cell Membrane
Gpi-Like-Anchor
Secreted
Cytoplasmic Vesicle
Clathrin-Coated Vesicle
Endosome
Endocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane
Alternative Antibody Names Anti-Folate Receptor Alpha antibody
Anti-Fr-Alpha antibody
Anti-Folate Receptor 1 antibody
Anti-Folate-Binding Protein 1 antibody
Anti-Folr1 antibody
Anti-Fbp1 antibody
Anti-Folbp1 antibody

Information sourced from Uniprot.org

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