| Tissue Specificity | Detected in kidney proximal tubules (at protein level). |
| Post Translational Modifications | The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption. |
| Protein Name | Folate Receptor AlphaFr-AlphaFolate Receptor 1Folate-Binding Protein 1 |
| Database Links | Reactome: R-MMU-204005Reactome: -MMU-5694530Reactome: -MMU-6807878 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorApical Cell MembraneBasolateral Cell MembraneGpi-Like-AnchorSecretedCytoplasmic VesicleClathrin-Coated VesicleEndosomeEndocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane |
| Alternative Antibody Names | Anti-Folate Receptor Alpha antibodyAnti-Fr-Alpha antibodyAnti-Folate Receptor 1 antibodyAnti-Folate-Binding Protein 1 antibodyAnti-Folr1 antibodyAnti-Fbp1 antibodyAnti-Folbp1 antibody |
Information sourced from Uniprot.org
