| Post Translational Modifications | The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis. The N-terminus is blocked. |
| Function | Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. |
| Protein Name | Glutamate Carboxypeptidase 2Cell Growth-Inhibiting Gene 27 ProteinFolate Hydrolase 1Folylpoly-Gamma-Glutamate CarboxypeptidaseFgcpGlutamate Carboxypeptidase IiGcpiiMembrane Glutamate CarboxypeptidaseMgcpN-Acetylated-Alpha-Linked Acidic Dipeptidase INaaladase IProstate-Specific Membrane AntigenPsmPsmaPteroylpoly-Gamma-Glutamate Carboxypeptidase |
| Database Links | Reactome: R-HSA-8963693 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinIsoform Psma': Cytoplasm |
| Alternative Antibody Names | Anti-Glutamate Carboxypeptidase 2 antibodyAnti-Cell Growth-Inhibiting Gene 27 Protein antibodyAnti-Folate Hydrolase 1 antibodyAnti-Folylpoly-Gamma-Glutamate Carboxypeptidase antibodyAnti-Fgcp antibodyAnti-Glutamate Carboxypeptidase Ii antibodyAnti-Gcpii antibodyAnti-Membrane Glutamate Carboxypeptidase antibodyAnti-Mgcp antibodyAnti-N-Acetylated-Alpha-Linked Acidic Dipeptidase I antibodyAnti-Naaladase I antibodyAnti-Prostate-Specific Membrane Antigen antibodyAnti-Psm antibodyAnti-Psma antibodyAnti-Pteroylpoly-Gamma-Glutamate Carboxypeptidase antibodyAnti-FOLH1 antibodyAnti-FOLH antibodyAnti-NAALAD1 antibodyAnti-PSM antibodyAnti-PSMA antibodyAnti-GIG27 antibody |
Information sourced from Uniprot.org
