| Host: |
Mouse |
| Applications: |
IHC-P |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Folate Receptor Alpha is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
BN3.2 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
Tissue culture supernatant with 15mM Sodium azide |
| Concentration: |
>=67 mg/L |
| Dilution Range: |
IHC-P 1:100 |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Gene Symbol: |
FOLR1 |
| Gene ID: |
2348 |
| Uniprot ID: |
FOLR1_HUMAN |
| Immunogen: |
Prokaryotic recombinant protein corresponding to 189 amino acids of the external domain of the folate receptor alpha molecule. |
| Tissue Specificity | Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium. |
| Post Translational Modifications | The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. |
| Protein Name | Folate Receptor AlphaFr-AlphaAdult Folate-Binding ProteinFbpFolate Receptor 1Folate Receptor - AdultKb Cells FbpOvarian Tumor-Associated Antigen Mov18 |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-5694530Reactome: R-HSA-6807878 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorApical Cell MembraneBasolateral Cell MembraneGpi-Like-AnchorSecretedCytoplasmic VesicleClathrin-Coated VesicleEndosomeEndocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane |
| Alternative Antibody Names | Anti-Folate Receptor Alpha antibodyAnti-Fr-Alpha antibodyAnti-Adult Folate-Binding Protein antibodyAnti-Fbp antibodyAnti-Folate Receptor 1 antibodyAnti-Folate Receptor - Adult antibodyAnti-Kb Cells Fbp antibodyAnti-Ovarian Tumor-Associated Antigen Mov18 antibodyAnti-FOLR1 antibodyAnti-FOLR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
