| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FNTA (280-379) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FNTA |
| Gene ID: |
2339 |
| Uniprot ID: |
FNTA_HUMAN |
| Immunogen Region: |
280-379 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 280-379 of human FNTA (NP_002018.1). |
| Immunogen Sequence: |
LKGILQDRGLSKYPNLLNQL LDLQPSHSSPYLIAFLVDIY EDMLENQCDNKEDILNKALE LCEILAKEKDTIRKEYWRYI GRSLQSKHSTENDSPTNVQQ |
| Post Translational Modifications | Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA. |
| Function | Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. |
| Protein Name | Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit AlphaCaax Farnesyltransferase Subunit AlphaFtase-AlphaRas Proteins Prenyltransferase Subunit AlphaType I Protein Geranyl-Geranyltransferase Subunit AlphaGgtase-I-Alpha |
| Database Links | Reactome: R-HSA-111465Reactome: R-HSA-2514859Reactome: R-HSA-9648002Reactome: R-HSA-9679191 |
| Alternative Antibody Names | Anti-Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha antibodyAnti-Caax Farnesyltransferase Subunit Alpha antibodyAnti-Ftase-Alpha antibodyAnti-Ras Proteins Prenyltransferase Subunit Alpha antibodyAnti-Type I Protein Geranyl-Geranyltransferase Subunit Alpha antibodyAnti-Ggtase-I-Alpha antibodyAnti-FNTA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
