| Tissue Specificity | Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen. |
| Post Translational Modifications | The extracellular domain is cleaved and released from the cell membrane. N-Glycosylated. |
| Function | Irisin: Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. |
| Protein Name | Fibronectin Type Iii Domain-Containing Protein 5Fibronectin Type Iii Repeat-Containing Protein 2 Cleaved Into - Irisin |
| Database Links | |
| Cellular Localisation | Fibronectin Type Iii Domain-Containing Protein 5: Cell MembraneSingle-Pass Membrane ProteinPeroxisome MembraneImported Into Peroxisomes Through The Pex5 Receptor PathwayIrisin: SecretedDetected In Plasma Following Endurance Exercise |
| Alternative Antibody Names | Anti-Fibronectin Type Iii Domain-Containing Protein 5 antibodyAnti-Fibronectin Type Iii Repeat-Containing Protein 2 Cleaved Into - Irisin antibodyAnti-FNDC5 antibodyAnti-FRCP2 antibody |
Information sourced from Uniprot.org
