• Western blot analysis of HUVEC, using FNDC4 antibody (STJ117124) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.

Anti-FNDC4 antibody (45-167) (STJ117124)

SKU:
STJ117124

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FNDC4 (45-167) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:100-1:500
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FNDC4
Gene ID: 64838
Uniprot ID: FNDC4_HUMAN
Immunogen Region: 45-167
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 45-167 of human FNDC4 (NP_073734.1).
Immunogen Sequence: DRPPSPVNVTVTHLRANSAT VSWDVPEGNIVIGYSISQQR QNGPGQRVIREVNTTTRACA LWGLAEDSDYTVQVRSIGLR GESPPGPRVHFRTLKGSDRL PSNSSSPGDITVEGLDGERP LQT
Tissue Specificity Up-regulated in colon cells of patients with inflammatory bowel disease (IBD).
Function Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to down-regulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by down-regulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis.
Protein Name Fibronectin Type Iii Domain-Containing Protein 4
Fibronectin Type Iii Repeat-Containing Protein 1
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Secreted
The N-Terminus Is Probably Cleaved To Release A Secreted Extracellular Portion Of The Protein
Alternative Antibody Names Anti-Fibronectin Type Iii Domain-Containing Protein 4 antibody
Anti-Fibronectin Type Iii Repeat-Containing Protein 1 antibody
Anti-FNDC4 antibody
Anti-FRCP1 antibody
Anti-UNQ6389 antibody
Anti-PRO21134 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance