| Host: |
Rabbit |
| Applications: |
WB/IHC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Formin-Binding Protein 1-Like is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Purification: |
Antigen affinity purification |
| Concentration: |
0.9 mg/mL |
| Dilution Range: |
WB 1:500-1:2000, IHC 1:20-1:100 |
| Storage Instruction: |
Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Function | Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. |
| Protein Name | Formin-Binding Protein 1-LikeTransducer Of Cdc42-Dependent Actin Assembly Protein 1Toca-1 |
| Database Links | Reactome: R-HSA-8856828Reactome: R-HSA-9013148Reactome: R-HSA-9013409 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexCytoplasmic VesicleCell MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Formin-Binding Protein 1-Like antibodyAnti-Transducer Of Cdc42-Dependent Actin Assembly Protein 1 antibodyAnti-Toca-1 antibodyAnti-FNBP1L antibodyAnti-C1orf39 antibodyAnti-TOCA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
