| Function | Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. |
| Protein Name | Formin-Binding Protein 1-LikeTransducer Of Cdc42-Dependent Actin Assembly Protein 1Toca-1 |
| Database Links | Reactome: R-HSA-8856828Reactome: R-HSA-9013148Reactome: R-HSA-9013409 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexCytoplasmic VesicleCell MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Formin-Binding Protein 1-Like antibodyAnti-Transducer Of Cdc42-Dependent Actin Assembly Protein 1 antibodyAnti-Toca-1 antibodyAnti-FNBP1L antibodyAnti-C1orf39 antibodyAnti-TOCA1 antibody |
Information sourced from Uniprot.org
