| Tissue Specificity | Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain. |
| Function | Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation. Specifically catalyzes S-oxygenation of sulfur derived compounds such as thioureas-derived compounds, thioetherorganophosphates to their sulfenic acid. In vitro, catalyzes S-oxygenation of the second-line antitubercular drugs thiacetazone (TAZ) and ethionamide (ETA), forming a sulfinic acid and a carbodiimide via a postulated sulfenic acid intermediate. Also catalyzes S-oxygenation of the thioether-containing organophosphate insecticides, phorate and disulfoton. |
| Protein Name | Flavin-Containing Monooxygenase 2Dimethylaniline Oxidase 2Fmo 1b1Pulmonary Flavin-Containing Monooxygenase 2Fmo 2 |
| Database Links | Reactome: R-HSA-217271 |
| Cellular Localisation | Microsome MembraneSingle-Pass Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Flavin-Containing Monooxygenase 2 antibodyAnti-Dimethylaniline Oxidase 2 antibodyAnti-Fmo 1b1 antibodyAnti-Pulmonary Flavin-Containing Monooxygenase 2 antibodyAnti-Fmo 2 antibodyAnti-FMO2 antibody |
Information sourced from Uniprot.org
