| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Leucine-rich repeat transmembrane protein FLRT2 (170-250 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FLRT2 |
| Gene ID: | 23768 |
| Uniprot ID: | FLRT2_HUMAN |
| Immunogen Region: | 170-250 aa |
| Specificity: | FLRT2 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 170-250 |
| Post Translational Modifications | N-glycosylated. Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease. |
| Function | Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis. |
| Protein Name | Leucine-Rich Repeat Transmembrane Protein Flrt2 Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 2 |
| Database Links | Reactome: R-HSA-5654687 |
| Cellular Localisation | Cell Membrane Single-Pass Membrane Protein Endoplasmic Reticulum Membrane Cell Junction Focal Adhesion Secreted Extracellular Space Extracellular Matrix Microsome Membrane Synapse Synaptosome Proteolytic Cleavage Gives Rise To A Shedded Ectodomain |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat Transmembrane Protein Flrt2 antibody Anti-Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 2 antibody Anti-FLRT2 antibody Anti-KIAA0405 antibody Anti-UNQ232 antibody Anti-PRO265 antibody |
Information sourced from Uniprot.org