| Host: |
Goat |
| Applications: |
Pep-ELISA |
| Reactivity: |
Human/Mouse/Rat/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-FLNB (Internal) is suitable for use in ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
FLNB |
| Gene ID: |
2317 |
| Uniprot ID: |
FLNB_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_001448.2; NP_001157789.1; NP_001157790.1; NP_001157791.1 |
| Specificity: |
This antibody is expected to recognise all reported isoforms (NP_001448.2; NP_001157789.1; NP_001157790.1; NP_001157791.1). |
| Immunogen Sequence: |
KITDDSRRCSQVK |
| Post Translational Modifications | ISGylation prevents ability to interact with the upstream activators of the JNK cascade and inhibits IFNA-induced JNK signaling. Ubiquitination by a SCF-like complex containing ASB2 isoform 1 leads to proteasomal degradation which promotes muscle differentiation. |
| Function | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| Protein Name | Filamin-BFln-BAbp-278Abp-280 HomologActin-Binding-Like ProteinBeta-FilaminFilamin Homolog 1Fh1Filamin-3Thyroid AutoantigenTruncated Actin-Binding ProteinTruncated Abp |
| Database Links | Reactome: R-HSA-1169408 |
| Cellular Localisation | Isoform 1: CytoplasmCell CortexCytoplasmCytoskeletonStress FiberMyofibrilSarcomereZ LineIn Differentiating MyotubesIsoform 1Isoform 2 And Isoform 3 Are Localized Diffusely Throughout The Cytoplasm With Regions Of Enrichment At The Longitudinal Actin Stress FiberIn Differentiated TubesIsoform 1 Is Also Detected Within The Z-LinesIsoform 2: CytoplasmIsoform 3: CytoplasmIsoform 6: CytoplasmPolarized At The Periphery Of Myotubes |
| Alternative Antibody Names | Anti-Filamin-B antibodyAnti-Fln-B antibodyAnti-Abp-278 antibodyAnti-Abp-280 Homolog antibodyAnti-Actin-Binding-Like Protein antibodyAnti-Beta-Filamin antibodyAnti-Filamin Homolog 1 antibodyAnti-Fh1 antibodyAnti-Filamin-3 antibodyAnti-Thyroid Autoantigen antibodyAnti-Truncated Actin-Binding Protein antibodyAnti-Truncated Abp antibodyAnti-FLNB antibodyAnti-FLN1L antibodyAnti-FLN3 antibodyAnti-TABP antibodyAnti-TAP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
