| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Filaggrin-2 (402-452 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FLG2 |
| Gene ID: |
388698 |
| Uniprot ID: |
FILA2_HUMAN |
| Immunogen Region: |
402-452 aa |
| Specificity: |
This antibody detects endogenous levels of FILA2 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human FILA2 at the amino acid range 402-452 |
| Post Translational Modifications | Deiminated by PADI1, PADI2 or PADI3 in vitro. The deiminated form is degraded by calpain-1/CAPN1 more quickly and into shorter peptides than the intact protein. May be processed by calpain-1/CAPN1 in the uppermost epidermal layers. |
| Function | Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. |
| Protein Name | Filaggrin-2Flg-2Intermediate Filament-Associated And Psoriasis-Susceptibility ProteinIfapsoriasin |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmCytoplasmic GranuleIn The Stratum Corneum Of The EpidermisDispersed Diffusely Throughout The CytoplasmWhile In The Stratum GranulosumLocalized Within Keratohyalin GranulesIn Granular Keratinocytes And In Lower CorneocytesColocalizes With Calpain-1/Capn1 |
| Alternative Antibody Names | Anti-Filaggrin-2 antibodyAnti-Flg-2 antibodyAnti-Intermediate Filament-Associated And Psoriasis-Susceptibility Protein antibodyAnti-Ifapsoriasin antibodyAnti-FLG2 antibodyAnti-IFPS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
