| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S2MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ALOX5AP |
| Gene ID: | 241 |
| Uniprot ID: | AL5AP_HUMAN |
| Immunogen Region: | 62-161 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 62-161 of human FLAP (P20292). |
| Immunogen Sequence: | DAYPTFLAVLWSAGLLCSQV PAAFAGLMYLFVRQKYFVGY LGERTQSTPGYIFGKRIILF LFLMSVAGIFNYYLIFFFGS DFENYIKTISTTISPLLLIP |
| Function | Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. |
| Protein Name | Arachidonate 5-Lipoxygenase-Activating ProteinFlapMk-886-Binding Protein |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-2142691Reactome: R-HSA-2142700 |
| Cellular Localisation | Nucleus MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Arachidonate 5-Lipoxygenase-Activating Protein antibodyAnti-Flap antibodyAnti-Mk-886-Binding Protein antibodyAnti-ALOX5AP antibodyAnti-FLAP antibody |
Information sourced from Uniprot.org