Anti-FKTN antibody (111-160 aa) (STJ192563)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 111-160
General Information
| Short Description | Rabbit polyclonal anti-Ribitol-5-phosphate transferase FKTN (111-160 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FKTN |
| Gene ID | 2218 |
| Uniprot ID | FKTN_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 111-160 |
| Immunogen Region | 111-160 aa |
| Specificity | FKTN Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Catalyzes the transfer of a ribitol-phosphate from CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1. Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development (Probable). |
| Protein Name | Ribitol-5-Phosphate Transferase FktnFukutinFukuyama-Type Congenital Muscular Dystrophy ProteinRibitol-5-Phosphate Transferase |
| Database Links | |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinCytoplasmNucleusIn Retinal TissueDoes Not Localize With The Golgi Apparatus |
| Alternative Antibody Names | Anti-Ribitol-5-Phosphate Transferase Fktn antibodyAnti-Fukutin antibodyAnti-Fukuyama-Type Congenital Muscular Dystrophy Protein antibodyAnti-Ribitol-5-Phosphate Transferase antibodyAnti-FKTN antibodyAnti-FCMD antibody |
Information sourced from Uniprot.org