| Function | Catalyzes the transfer of a ribitol-phosphate from CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1. Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development (Probable). |
| Protein Name | Ribitol-5-Phosphate Transferase FktnFukutinFukuyama-Type Congenital Muscular Dystrophy ProteinRibitol-5-Phosphate Transferase |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinCytoplasmNucleusIn Retinal TissueDoes Not Localize With The Golgi Apparatus |
| Alternative Antibody Names | Anti-Ribitol-5-Phosphate Transferase Fktn antibodyAnti-Fukutin antibodyAnti-Fukuyama-Type Congenital Muscular Dystrophy Protein antibodyAnti-Ribitol-5-Phosphate Transferase antibodyAnti-FKTN antibodyAnti-FCMD antibody |
Information sourced from Uniprot.org
