Anti-FKBP8 antibody (60-270) (STJ29165)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FKBP8 (60-270) antibody for use in WB, IF, ICC, IP and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/IP/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:100IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FKBP8 |
| Gene ID | 23770 |
| Uniprot ID | FKBP8_HUMAN |
| Immunogen Region | 60-270 |
| Immunogen Sequence | QPPAEEAEQPGALAREFLAA MEPEPAPAPAPEEWLDILGN GLLRKKTLVPGPPGSSRPVK GQVVTVHLQTSLENGTRVQE EPELVFTLGDCDVIQALDLS VPLMDVGETAMVTADSKYCY GPQGSRSPYIPPHAALCLEV TLKTAVDGPDLEMLTGQERV ALANRKRECGNAHYQRADFV LAANSYDLAIKAITSSAKVD MTFEEEAQLLQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 60-270 of human FKBP38/FKBP38/FKBP8 (NP_036313.3). |
Additional Info
| Tissue Specificity | Widely expressed. Highest levels seen in the brain. Highly abundant in the retina. |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV). |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp8Ppiase Fkbp838 Kda Fk506-Binding Protein38 Kda FkbpFkbp-38Hfkbp38Fk506-Binding Protein 8Fkbp-8Fkbpr38Rotamase |
| Database Links | Reactome: R-HSA-5689880 |
| Cellular Localisation | MitochondrionMitochondrion MembraneSingle-Pass Membrane ProteinCytoplasmic SideIsoform 1: Mitochondrion MembraneIsoform 3: Mitochondrion Membrane |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase Fkbp8 antibodyAnti-Ppiase Fkbp8 antibodyAnti-38 Kda Fk506-Binding Protein antibodyAnti-38 Kda Fkbp antibodyAnti-Fkbp-38 antibodyAnti-Hfkbp38 antibodyAnti-Fk506-Binding Protein 8 antibodyAnti-Fkbp-8 antibodyAnti-Fkbpr38 antibodyAnti-Rotamase antibodyAnti-FKBP8 antibodyAnti-FKBP38 antibody |
Information sourced from Uniprot.org