| Host: | Rabbit |
| Applications: | WB/IF/ICC/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:100 IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cells ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FKBP8 |
| Gene ID: | 23770 |
| Uniprot ID: | FKBP8_HUMAN |
| Immunogen Region: | 60-270 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-270 of human FKBP38/FKBP38/FKBP8 (NP_036313.3). |
| Immunogen Sequence: | QPPAEEAEQPGALAREFLAA MEPEPAPAPAPEEWLDILGN GLLRKKTLVPGPPGSSRPVK GQVVTVHLQTSLENGTRVQE EPELVFTLGDCDVIQALDLS VPLMDVGETAMVTADSKYCY GPQGSRSPYIPPHAALCLEV TLKTAVDGPDLEMLTGQERV ALANRKRECGNAHYQRADFV LAANSYDLAIKAITSSAKVD MTFEEEAQLLQ |
| Tissue Specificity | Widely expressed. Highest levels seen in the brain. Highly abundant in the retina. |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV). |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp8 Ppiase Fkbp8 38 Kda Fk506-Binding Protein 38 Kda Fkbp Fkbp-38 Hfkbp38 Fk506-Binding Protein 8 Fkbp-8 Fkbpr38 Rotamase |
| Database Links | Reactome: R-HSA-5689880 |
| Cellular Localisation | Mitochondrion Mitochondrion Membrane Single-Pass Membrane Protein Cytoplasmic Side Isoform 1: Mitochondrion Membrane Isoform 3: Mitochondrion Membrane |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase Fkbp8 antibody Anti-Ppiase Fkbp8 antibody Anti-38 Kda Fk506-Binding Protein antibody Anti-38 Kda Fkbp antibody Anti-Fkbp-38 antibody Anti-Hfkbp38 antibody Anti-Fk506-Binding Protein 8 antibody Anti-Fkbp-8 antibody Anti-Fkbpr38 antibody Anti-Rotamase antibody Anti-FKBP8 antibody Anti-FKBP38 antibody |
Information sourced from Uniprot.org