Anti-FKBP5 antibody (308-457) (STJ117806)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FKBP5 (308-457) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FKBP5 |
| Gene ID | 2289 |
| Uniprot ID | FKBP5_HUMAN |
| Immunogen Region | 308-457 |
| Immunogen Sequence | ESKASESFLLAAFLNLAMCY LKLREYTKAVECCDKALGLD SANEKGLYRRGEAQLLMNEF ESAKGDFEKVLEVNPQNKAA RLQISMCQKKAKEHNERDRR IYANMFKKFAEQDAKEEANK AMGKKTSEGVTNEKGTDSQA MEEEKPEGHV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 308-457 of human FKBP51/FKBP5 (NP_001139247.1). |
Additional Info
| Tissue Specificity | Widely expressed, enriched in testis compared to other tissues. |
| Post Translational Modifications | Acetylation impairs ability to promote interaction between Akt/AKT1 and PHLPP1. Deacetylation by SIRT7 promotes interaction between Akt/AKT1 and PHLPP1, leading to suppress Akt/AKT1 activation. Ubiquitinated, leading to degradation in a proteasome-dependent manner. Deubiquitinated by USP49, leading to stabilization. |
| Function | Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp5Ppiase Fkbp551 Kda Fk506-Binding Protein51 Kda FkbpFkbp-5154 Kda Progesterone Receptor-Associated ImmunophilinAndrogen-Regulated Protein 6Ff1 AntigenFk506-Binding Protein 5Fkbp-5Fkbp54P54Hsp90-Binding ImmunophilinRotamase |
| Database Links | Reactome: R-HSA-3371497Reactome: R-HSA-8939211Reactome: R-HSA-9022699Reactome: R-HSA-9909505 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase Fkbp5 antibodyAnti-Ppiase Fkbp5 antibodyAnti-51 Kda Fk506-Binding Protein antibodyAnti-51 Kda Fkbp antibodyAnti-Fkbp-51 antibodyAnti-54 Kda Progesterone Receptor-Associated Immunophilin antibodyAnti-Androgen-Regulated Protein 6 antibodyAnti-Ff1 Antigen antibodyAnti-Fk506-Binding Protein 5 antibodyAnti-Fkbp-5 antibodyAnti-Fkbp54 antibodyAnti-P54 antibodyAnti-Hsp90-Binding Immunophilin antibodyAnti-Rotamase antibodyAnti-FKBP5 antibodyAnti-AIG6 antibodyAnti-FKBP51 antibody |
Information sourced from Uniprot.org