Anti-FKBP5 antibody [3000000000] (STJA0032631)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenFull length human recombinant protein of human FKBP5 produced in 293T cell.
General Information
| Short Description | Mouse monoclonal anti-FKBP5 for use in WB and IHC-P in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 3000000000 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100 |
| Formulation | Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | FKBP5 |
| Gene ID | 2289 |
| Uniprot ID | FKBP5_HUMAN |
| Immunogen | Full length human recombinant protein of human FKBP5 produced in 293T cell. |
Additional Info
| Tissue Specificity | Widely expressed, enriched in testis compared to other tissues. |
| Post Translational Modifications | Acetylation impairs ability to promote interaction between Akt/AKT1 and PHLPP1. Deacetylation by SIRT7 promotes interaction between Akt/AKT1 and PHLPP1, leading to suppress Akt/AKT1 activation. Ubiquitinated, leading to degradation in a proteasome-dependent manner. Deubiquitinated by USP49, leading to stabilization. |
| Function | Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp5Ppiase Fkbp551 Kda Fk506-Binding Protein51 Kda FkbpFkbp-5154 Kda Progesterone Receptor-Associated ImmunophilinAndrogen-Regulated Protein 6Ff1 AntigenFk506-Binding Protein 5Fkbp-5Fkbp54P54Hsp90-Binding ImmunophilinRotamase |
| Database Links | Reactome: R-HSA-3371497Reactome: R-HSA-8939211Reactome: R-HSA-9022699Reactome: R-HSA-9909505 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase Fkbp5 antibodyAnti-Ppiase Fkbp5 antibodyAnti-51 Kda Fk506-Binding Protein antibodyAnti-51 Kda Fkbp antibodyAnti-Fkbp-51 antibodyAnti-54 Kda Progesterone Receptor-Associated Immunophilin antibodyAnti-Androgen-Regulated Protein 6 antibodyAnti-Ff1 Antigen antibodyAnti-Fk506-Binding Protein 5 antibodyAnti-Fkbp-5 antibodyAnti-Fkbp54 antibodyAnti-P54 antibodyAnti-Hsp90-Binding Immunophilin antibodyAnti-Rotamase antibodyAnti-FKBP5 antibodyAnti-AIG6 antibodyAnti-FKBP51 antibody |
Information sourced from Uniprot.org