| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Peptidyl-prolyl cis-trans isomerase FKBP4 is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FKBP4 |
| Gene ID: | 2288 |
| Uniprot ID: | FKBP4_HUMAN |
| Specificity: | FKBP4 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Phosphorylation by CK2 results in loss of HSP90 binding activity. |
| Function | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 Ppiase Fkbp4 51 Kda Fk506-Binding Protein Fkbp51 52 Kda Fk506-Binding Protein 52 Kda Fkbp Fkbp-52 59 Kda Immunophilin P59 Fk506-Binding Protein 4 Fkbp-4 Fkbp59 Hsp-Binding Immunophilin Hbi Immunophilin Fkbp52 Rotamase Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-3371497 Reactome: R-HSA-3371568 Reactome: R-HSA-8939211 Reactome: R-HSA-9018519 Reactome: R-HSA-9679191 |
| Cellular Localisation | Cytoplasm Cytosol Mitochondrion Nucleus Cytoskeleton Cell Projection Axon Shuttles From Mitochondria To Nucleus Co-Localizes In Mitochondria With The Glucocorticoid Receptor Colocalized With Mapt/Tau In The Distal Part Of The Primary Cortical Neurons |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 antibody Anti-Ppiase Fkbp4 antibody Anti-51 Kda Fk506-Binding Protein antibody Anti-Fkbp51 antibody Anti-52 Kda Fk506-Binding Protein antibody Anti-52 Kda Fkbp antibody Anti-Fkbp-52 antibody Anti-59 Kda Immunophilin antibody Anti-P59 antibody Anti-Fk506-Binding Protein 4 antibody Anti-Fkbp-4 antibody Anti-Fkbp59 antibody Anti-Hsp-Binding Immunophilin antibody Anti-Hbi antibody Anti-Immunophilin Fkbp52 antibody Anti-Rotamase Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 - N-Terminally Processed antibody Anti-FKBP4 antibody Anti-FKBP52 antibody |
Information sourced from Uniprot.org