| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FKBP1A |
| Gene ID: | 2280 |
| Uniprot ID: | FKB1A_HUMAN |
| Immunogen Region: | 2-108 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 2-108 of FKBP12 (NP_000792.1). |
| Immunogen Sequence: | GVQVETISPGDGRTFPKRGQ TCVVHYTGMLEDGKKFDSSR DRNKPFKFMLGKQEVIRGWE EGVAQMSVGQRAKLTISPDY AYGATGHPGIIPPHATLVFD VELLKLE |
| Function | Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp1aPpiase Fkbp1a12 Kda Fk506-Binding Protein12 Kda FkbpFkbp-12Calstabin-1Fk506-Binding Protein 1aFkbp-1aImmunophilin Fkbp12Rotamase |
| Database Links | Reactome: R-HSA-166208Reactome: R-HSA-2025928Reactome: R-HSA-2173789Reactome: R-HSA-2173791Reactome: R-HSA-3656535Reactome: R-HSA-9679191Reactome: R-HSA-9692916 |
| Cellular Localisation | CytoplasmCytosolSarcoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase Fkbp1a antibodyAnti-Ppiase Fkbp1a antibodyAnti-12 Kda Fk506-Binding Protein antibodyAnti-12 Kda Fkbp antibodyAnti-Fkbp-12 antibodyAnti-Calstabin-1 antibodyAnti-Fk506-Binding Protein 1a antibodyAnti-Fkbp-1a antibodyAnti-Immunophilin Fkbp12 antibodyAnti-Rotamase antibodyAnti-FKBP1A antibodyAnti-FKBP1 antibodyAnti-FKBP12 antibody |
Information sourced from Uniprot.org