| Tissue Specificity | Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at protein level). Expressed in ovarian epithelial cells. Down-regulated in ovarian cancer. |
| Function | Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. |
| Protein Name | Filamin A-Interacting Protein 1-Like130 Kda Gpbp-Interacting Protein90 Kda Gpbp-Interacting ProteinProtein Down-Regulated In Ovarian Cancer 1Doc-1 |
| Cellular Localisation | CytoplasmMembraneNucleus |
| Alternative Antibody Names | Anti-Filamin A-Interacting Protein 1-Like antibodyAnti-130 Kda Gpbp-Interacting Protein antibodyAnti-90 Kda Gpbp-Interacting Protein antibodyAnti-Protein Down-Regulated In Ovarian Cancer 1 antibodyAnti-Doc-1 antibodyAnti-FILIP1L antibodyAnti-COL4A3BPIP antibodyAnti-DOC1 antibodyAnti-GIP90 antibody |
Information sourced from Uniprot.org
