Anti-FHL2 antibody (50-260) [S9MR] (STJ11101919)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal FHL2 (50-260) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S9MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FHL2 |
| Gene ID | 2274 |
| Uniprot ID | FHL2_HUMAN |
| Immunogen Region | 50-260 |
| Immunogen Sequence | DCKDLSYKDRHWHEACFHCS QCRNSLVDKPFAAKEDQLLC TDCYSNEYSSKCQECKKTIM PGTRKMEYKGSSWHETCFIC HRCQQPIGTKSFIPKDNQNF CVPCYEKQHAMQCVQCKKPI TTGGVTYREQPWHKECFVCT ACRKQLSGQRFTARDDFAYC LNCFCDLYAKKCAGCTNPIS GLGGTKYISFEERQWHNDCF NCKKCSLSLVG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 50-260 of human FHL2 (Q14192). |
Additional Info
| Tissue Specificity | Expressed in skeletal muscle and heart. |
| Function | May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. |
| Protein Name | Four And A Half Lim Domains Protein 2Fhl-2Lim Domain Protein DralSkeletal Muscle Lim-Protein 3Slim-3 |
| Database Links | Reactome: R-HSA-1989781 |
| Cellular Localisation | CytoplasmNucleusMyofibrilSarcomereZ Line |
| Alternative Antibody Names | Anti-Four And A Half Lim Domains Protein 2 antibodyAnti-Fhl-2 antibodyAnti-Lim Domain Protein Dral antibodyAnti-Skeletal Muscle Lim-Protein 3 antibodyAnti-Slim-3 antibodyAnti-FHL2 antibodyAnti-DRAL antibodyAnti-SLIM3 antibody |
Information sourced from Uniprot.org